Gunslinger Girl - S01

Set in modern Italy, the story follows a group of traumatically injured young girls taken from hospitals across the country, who are then cybernetically enhanced, indoctrinated, and trained as assassins by a secret branch of the Public Corporation for Social Welfare, Section 2. Each girl is assigned a male "handler" who oversees her training, deployments, and general conduct. Each handler is free to "condition" his cybernetic assassin as much as he sees fit, which increases a girl's lethality and loyalty at the expense of her human individuality and lifespan.